ABSTRACT
Pengabdian ini dilaksanakan sebagai wujud kontribusi Unimma untuk pencegahan penularan COVID-19 pemutusan rantai penyebaran COVID-19 dan meningkatkan ketahanan masyarakat untuk siaga dan sigap sehingga menjadi desa tangguh menghadapi bencana wabah COVID-19. Pendekatan participatory rural appraisal diaplikasikan dalam studi pengabdian ini. Kegiatan yang dilaksanakan adalah membagikan masker dan sabun pada masyarakat;penyemprotan desinfektan guna mensterilkan lingkungan dusun dari virus COVID-19;membagikan sembako;dan menjaga posko COVID-19 selama 30 hari. Hasil kegiatan ini adalah untuk meningkatnya kesadaran masyarakat dalam bentuk kebiasaan seusai protokol Kesehatan semangat saling menjaga dan gotong royong kebutuhan selama pandemi. Selama kegiatan ini berlangsung masih ada warga yang belum mengetahui bahaya virus COVID-19 dan masih terdapat juga warga yang menganggap remeh virus COVID-19.
ABSTRACT
PURPOSE: Statin potentially improved outcome in patients with COVID-19. Patients who receive statin generally have a higher proportion of comorbidities than those who did not, which may introduce bias. In this meta-analysis, we aimed to investigate the association between statin use and mortality in patients with COVID-19 by pooling the adjusted effect estimates from propensity-score matching (PSM) matched studies or randomised controlled trials to reduce bias. METHODS: A systematic literature search using the PubMed, Scopus and Embase databases were performed up until 1 March 2021. Studies that were designed the study to assess statin and mortality using PSM with the addition of Inverse Probability Treatment Weighting or multivariable regression analysis on top of PSM-matched cohorts were included. The effect estimate was reported in term of relative risk (RR). RESULTS: 14 446 patients were included in the eight PSM-matched studies. Statin was associated with decreased mortality in patients with COVID-19 (RR 0.72 (0.55, 0.95), p=0.018; I2: 84.3%, p<0.001). Subgroup analysis in patients receiving statin in-hospital showed that it was associated with lower mortality (RR 0.71 (0.54, 0.94), p=0.030; I2: 64.1%, p<0.025). The association of statin and mortality was not significantly affected by age (coefficient: -0.04, p=0.382), male gender (RR 0.96 (0.95, 1.02), p=0.456), diabetes (RR 1.02 (0.99, 1.04), p=0.271) and hypertension (RR 1.01 (0.97, 1.04), p=0.732) in this pooled analysis. CONCLUSION: In this meta-analysis of PSM-matched cohorts with adjusted analysis, statin was shown to decrease the risk of mortality in patients with COVID-19. PROSPERO REGISTRATION NUMBER: CRD42021240137.
Subject(s)
COVID-19 , Diabetes Mellitus , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Comorbidity , Diabetes Mellitus/drug therapy , Diabetes Mellitus/epidemiology , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Male , RiskABSTRACT
BACKGROUND/AIMS: The coronavirus disease 2019 (COVID-19) pandemic has necessitated modifications to allow the safe practice of clinical gastroenterology and gastrointestinal endoscopy. This study aimed to investigate the characteristics of clinical gastroenterology and gastrointestinal endoscopy practices during the COVID-19 pandemic in Indonesia. METHODS: This cross-sectional study enrolled physician members of the Indonesian Society for Digestive Endoscopy. We used an online self-administered questionnaire disseminated via social media. The 32-item survey determined the baseline characteristics of the participants, characteristics of clinical gastroenterology and gastrointestinal endoscopy practices, involvement of the physicians in the management of COVID-19, and overall impact of the pandemic on practice. All collected data were analyzed using descriptive statistics. RESULTS: The 200 participants in this study had a median age of 50 (34-76) years. Modifications in clinical gastroenterology practice were frequently reported in the outpatient (95.5%) and inpatient (100%) settings. All participants reported changes in the gastrointestinal endoscopy practice patterns. Of the participants, 86.0% were working in high-risk zones, and several of them reported inadequate protective personal equipment (34.0%). The median overall impact score of the pandemic on practice was 9 (2-10). CONCLUSION: Physicians practicing clinical gastroenterology and gastrointestinal endoscopy in Indonesia work in high-risk settings. Modifications in clinical gastroenterology and gastrointestinal endoscopy practices are prevalent during the COVID-19 pandemic.